Added Value of IP-10 as a Read-Out of Mycobacterium tuberculosis

نویسندگان

  • Synne Jenum
  • Sivakumaran Dhanasekaran
  • Christian Ritz
  • Ragini Macaden
  • T. Mark Doherty
  • Harleen M. S. Grewal
چکیده

We have explored the added value of interferon-γ (IFNγ)-inducible protein 10 as a read-out of Mycobacterium tuberculosis-specific immunity in young Indian children, where the sensitivity of the IFNγ release assays for tuberculosis is poor. Reduced frequency of indeterminate results and an increased sensitivity for tuberculosis suggest a potential for fewer missed cases with a combined IFNγ/inducible protein 10 read-out in a 4th generation IFNγ release assays.

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عنوان ژورنال:

دوره 35  شماره 

صفحات  -

تاریخ انتشار 2016